6 Reasons You’re Not Losing Weight on Wegovy

Congratulations on starting your weight loss journey! You've consulted with a healthcare provider and received a prescription for Wegovy, taking a significant first step in your fight against obesity.

However, after some time on Wegovy, you may find that the weight isn't coming off as expected. Why is that?

There could be several reasons why you aren't seeing the results you anticipated. This article will explore some of the most common factors affecting weight loss on Wegovy and offer guidance on what to do next.

What is WeGovy?

Wegovy (semaglutide) is a prescription weight loss medication developed by Novo Nordisk, designed to help individuals with overweight or obesity shed pounds and maintain their progress.

The active ingredient in Wegovy, semaglutide, is a glucagon-like peptide-1 receptor agonist (GLP-1). It mimics the natural hormone GLP-1, which helps regulate insulin release, decrease glucagon secretion, and slow stomach emptying, leading to better blood sugar control and increased feelings of fullness.

Unlike other GLP-1 medications like Ozempic or Rybelsus, Wegovy contains a higher dose of semaglutide and is FDA-approved specifically for weight management in adults and children over 12. It’s prescribed alongside lifestyle changes, such as diet and exercise, to help reduce calorie intake and curb cravings for high-fat or high-sugar foods.

Why am I Not Losing Weight?

If you're not reaching your weight loss goals while taking Wegovy, several factors could be at play:

1. You Need More Time

Weight loss takes time. On average, participants in clinical trials lost about 2% (around 5 lbs) of their body weight by the fourth week of Wegovy treatment. Results vary, with some losing more and others less. The longer you use Wegovy, the more noticeable the results become. After a 68-week trial, the average patient lost 15% (about 35 lbs) of their body weight, with over 30% losing 20% (46 lbs) or more. These results don’t happen overnight; they require over a year of weekly semaglutide injections and healthy lifestyle habits. Many people don’t see significant weight loss until around the 20-week mark. If you're feeling frustrated, consider how long you've been on the medication. If it’s been over 20 weeks, consult your provider to see if a higher dose might help you reach your goal. Be patient with yourself and the process.

2. You Need to Follow a Healthy, Reduced-Calorie Diet

Wegovy is most effective when combined with healthy lifestyle changes, including regular exercise and a nutritious diet. If you’re struggling to lose weight, consider whether you’re maintaining these practices. Unhealthy eating habits—like snacking between meals, overeating, or consuming a high-calorie diet—can hinder your progress. Talk to your provider about your diet to see if adjustments are needed. They may recommend focusing on nutrient-rich foods like vegetables, fruits, and whole grains while avoiding those high in saturated fats or sugar. A healthcare provider can help you develop a sustainable meal plan and caloric intake recommendations to ensure you're getting the nutrition you need.

3. You Need More Exercise

Clinical trials show that Wegovy is most effective when patients engage in at least 150 minutes of moderate-intensity aerobic exercise per week. This breaks down to just over 21 minutes per day and can include activities like brisk walking, swimming, dancing, cycling, or jogging. Even yard work counts! Regular aerobic exercise also reduces the risk of cardiovascular complications, such as high blood pressure. To avoid burnout or injury, work with your provider or a weight loss specialist to create an exercise regimen that suits your needs and experience level.

4. Stress Is Hindering Your Progress

High-stress levels are linked to overweight and obesity. Stress triggers the release of cortisol, a hormone that influences metabolism, increasing energy levels but also driving unhealthy cravings. Exercise is a great way to relieve stress and lower cortisol levels, providing the added benefits mentioned above. Incorporate other stress-reduction techniques, such as deep breathing and meditation, to support your weight loss journey.

5. You Need More Sleep

Getting enough sleep is crucial for managing stress and maintaining a healthy weight. Aim for 7-8 hours of sleep per night. Sleep deprivation is associated with elevated cortisol levels and a higher risk of obesity. Practice good sleep hygiene by maintaining a consistent sleep schedule, winding down before bed, and avoiding screens before sleep. Discuss your sleep habits with your healthcare provider to incorporate healthy sleep practices into your routine and start seeing the results you want.

6. You May Have an Underlying Health Condition

If you’re not losing weight on Wegovy despite your efforts, an underlying medical condition might be the culprit. Conditions like hypothyroidism and type 2 diabetes can make weight loss challenging. Additionally, certain medications, such as antipsychotics and some blood pressure medications, can cause weight gain or slow weight loss. If you’re following healthy habits while taking Wegovy and still not seeing results, talk to your provider. They may screen you for other health conditions. Before starting Wegovy, inform your provider about your medical history and current medications. This will reduce the risk of drug interactions and give your provider a fuller understanding of potential barriers to weight loss.

Weight Loss Treatment in Maryland

If you are struggling with your weight and looking for a change, we are here to help. Bowie Internal Medicine is committed to treating any conditions you may have, as well as preventing further health complications through preventative care. For more information, please contact our office to schedule an appointment or ask any questions.